反应详情

The crystals obtained in step d) were suspended in methanol (1 100 ml), the mixture was heated to reflux and sodium hydroxide solution (2M, 440 ml) was gradually added followed by water (350 ml). The mixture was cooled down to 10–15° C. Formed crystals were filtered and washed on filter with methanol (150 ml) and water (150 ml) mixture. Crystals were dried at 50° C. to give 340 g of product.

1. temperaturethe mixture was heated
2. temperatureto reflux
3. temperatureThe mixture was cooled down to 10–15° C
4. customFormed crystals
5. filtrationwere filtered
6. washwashed
7. filtrationon filter with methanol (150 ml) and water (150 ml) mixture
8. customCrystals were dried at 50° C.