HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium hydride → HCID 53712208, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | Diethyl phosphonomethanol | HCID 76513 | — |
| Reactant | 2-(Bromomethyl)-4,6-dimethylpyridine | HCID 22280405 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | HCID 53712208 | HCID 53712208 | — |
Reaction Steps
A solution of diethyl hydroxymethylphosphonate (1 mmole) in toluene was treated with sodium hydride (1.1 mmole) at 0° C., and after 15 min 2-bromomethyl-4,6-dimethylpyridine (1 mmole) was added. After 3 h the reaction mixture was subjected to extraction and chromatography to give 2-diethylphosphonomethyl-4,6-dimethylpyridine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06965033B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-c3fd683343b74673bac12df285c3506a |
| Source note | uspto-grants-2005_11 |