4-Methoxy-2-aminobenzothiazole → 2-Amino-4-hydroxybenzothiazole

HRID 1063606Notes

Reaction equation

HRID 1063606 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([O:11]C)[C:5]=2[N:6]=1>CCS>[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[CH:9][CH:8]=[C:7]([OH:11])[C:5]=2[N:6]=1

Participants

3

Reactant 1

HCID 216224-Methoxy-2-aminobenzothiazole

Product 1

HCID 240572-Amino-4-hydroxybenzothiazole

Reagents, catalysts & solvents 1

HCID 6343EthanethiolSolvent

Conditions

Temperature
2.5 °C

Procedure

A solution of AICl3 (5 mmole) in EtSH (10 mL) was cooled to 0° C. and treated with 2-amino-4-methoxybenzothiazole (1 mmole). The mixture was stirred at 0-5° C. for 2 h. Evaporation and extraction gave 2-amino-4-hydroxybenzothiazole as white solid.

Workup

  1. customEvaporation and extraction

Sources & evidence

ORD record
ord-2e5291c1c54e47c6958268d85d3c48c3
Source dataset
uspto-grants-2005_11
Patent number
US06965033B2

Reaction notes

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