Boron tribromide → HCID 22280699, compound

HRID 1063617Notes

Reaction equation

HRID 1063617 reaction equation
[NH2:1][C:2]1[S:3][C:4]2[C:10]([O:11][CH3:12])=[C:9]([Br:13])[CH:8]=[C:7]([O:14]C)[C:5]=2[N:6]=1.B(Br)(Br)Br>C(Cl)Cl>[NH2:1][C:2]1[S:3][C:4]2[C:10]([O:11][CH3:12])=[C:9]([Br:13])[CH:8]=[C:7]([OH:14])[C:5]=2[N:6]=1

Participants

4

Reactant 2

HCID 25134Boron tribromideHCID 22280476HCID 22280476, compound

Product 1

HCID 22280699HCID 22280699, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent2×

Procedure

To a solution of 1 mmol of 2-Amino-4,7-dimethoxy-6-bromo benzothiazole in CH2Cl2 was added 2.2 mmol of BBr3 in CH2Cl2 at 0° C. for 16 h. Aqueous work-up and chromatography gave 2-amino-4-hydroxy-6-bromo-7-methoxy benzothiazole.

Sources & evidence

ORD record
ord-15dccc2d0df94a1b85171ab0e14f1e36
Source dataset
uspto-grants-2005_11
Patent number
US06965033B2

Reaction notes

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