Lithium Hydroxide → HCID 178486061, compound

Participants

Reaction Steps

15.3 g (48.5 mmol) of trans-3-[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyloxy]-propionic acid methyl ester in 485 mL of THF were treated with 485 mL of 1M LiOH at RT for 1 h. The solution was acidified by adding 1M KHSO4, and the mixture was extracted with EtOAc. The organic phase was washed with brine, dried over Na2SO4 and evaporated. The crude product was triturated with n-heptane to give trans-3-[4-(tert-butoxycarbonyl-methyl-amino)-cyclohexyloxy]-propionic acid as white solid, MS: 300 (M−H)−.

Provenance & Evidence