Chloroform → HCID 178479210, compound

Participants

Reaction Steps

A solution of 24.2 g (90.5 mmol) of trans-[4-(tert-butyl-dimethyl-silanyloxymethyl)-cyclohexyl]-acetonitrile, 22 mL (270 mmol, 3 eq) of CHCl3 and 2.4 g of PtO2 (Degussa 223) in 250 mL of ethanol was stirred at RT for 20 h under a hydrogen atmosphere. The catalyst was then removed by filtration and the solvent evaporated under reduced pressure to give 17.1 g (97%) of pure trans-[4-(2-amino-ethyl)-cyclohexyl]-methanol-HCl-salt as colorless solid, MS: 158 (MH+).

Provenance & Evidence