Ethylmorpholine → HCID 178484646, compound

Participants

Reaction Steps

To a solution of 200 mg (0.67 mmol) of trans-{4-[2-(tert-butoxycarbonyl-methyl-amino)-ethyl]-cyclohexyl}-acetic acid and 0.065 mL (0.8 mmol, 1.2 eq) of 2-(methylamino)-ethanol were added 0.4 mL (3.3 mmol, 5 eq) of 4-ethylmorpholine and 0.31 g (0.7 mmol, 1.05 eq) of BOP at RT. The solution was stirred at RT for 3 h, diluted with ether and 1M HCl was added. The phases were separated and the organic phases were washed with water and brine and dried over magnesium sulfate. Evaporation yielded 234 mg (quantitative) of crude trans [2-(4-{[(2-hydroxy-ethyl)-methyl-carbamoyl]-methyl}-cyclohexyl)-ethyl]-methyl-carbamic acid tert-butyl ester as colorless oil, MS: 357 (MH+).

Provenance & Evidence