Lithium Hydroxide → HCID 178483653, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) and stirred solution of 0.39 g (0.87 mmol) of trans-3-[(4-{2-[(4-chloro-phenoxycarbonyl)-methyl-amino]-ethyl}-cyclohexanecarbonyl)-methyl-amino]-propionic acid ethyl ester in 2.6 mL of THF was added within 5 min 2.6 mL (2.6 mmol, 3 eq) of aqueous 1M LiOH and the solution was stirred at RT for 2.5 h. The reaction was partitioned between Et2O (×3)/aqueous 10% KHSO4. The organic phase was washed with 10% NaCl, dried over Na2SO4 and evaporated to yield 0.38 g (quantitative) of trans-3-[(4-{2-[(4-chloro-phenoxycarbonyl)-methyl-amino]-ethyl}-cyclohexanecarbonyl)-methyl-amino]-propionic acid, MS: 425 (MH+, 1Cl).

Provenance & Evidence