4-(4-Trifluoromethylphenyl)benzylchloride → [2-Methyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

HRID 1063657Notes

Reaction equation

HRID 1063657 reaction equation
Cl[CH2:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.C[O:20][C:21](=[O:32])[CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([SH:30])=[CH:26][C:25]=1[CH3:31]>>[CH3:31][C:25]1[CH:26]=[C:27]([S:30][CH2:2][C:3]2[CH:8]=[CH:7][C:6]([C:9]3[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=3)=[CH:5][CH:4]=2)[CH:28]=[CH:29][C:24]=1[O:23][CH2:22][C:21]([OH:32])=[O:20]

Participants

3

Reactant 2

HCID 114599214-(4-Trifluoromethylphenyl)benzylchlorideHCID 20770797Methyl (2-methyl-4-sulfanylphenoxy)acetate

Product 1

HCID 22280134[2-Methyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using 3B and 2C. MS m/z 447 (M+1).

Sources & evidence

ORD record
ord-dbaef31f0ad749c7bfa1e2a8f59be4f8
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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