[5-Methoxy-2-methyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid methyl ester → [5-Methoxy-2-methyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

HRID 1063660Notes

Reaction equation

HRID 1063660 reaction equation
C[O:2][C:3](=[O:33])[CH2:4][O:5][C:6]1[CH:11]=[C:10]([O:12][CH3:13])[C:9]([S:14][CH2:15][C:16]2[CH:21]=[CH:20][C:19]([C:22]3[CH:27]=[CH:26][C:25]([C:28]([F:31])([F:30])[F:29])=[CH:24][CH:23]=3)=[CH:18][CH:17]=2)=[CH:8][C:7]=1[CH3:32]>O>[CH3:13][O:12][C:10]1[C:9]([S:14][CH2:15][C:16]2[CH:17]=[CH:18][C:19]([C:22]3[CH:23]=[CH:24][C:25]([C:28]([F:30])([F:31])[F:29])=[CH:26][CH:27]=3)=[CH:20][CH:21]=2)=[CH:8][C:7]([CH3:32])=[C:6]([CH:11]=1)[O:5][CH2:4][C:3]([OH:33])=[O:2]

Participants

3

Reactant 1

HCID 11454360[5-Methoxy-2-methyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid methyl ester

Product 1

HCID 9825600[5-Methoxy-2-methyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared in the manner analogous to Example 1 using 4A. mp 170-171° C.; 400 MHz 1H NMR (DMSO-d6) δ 7.81 (d, 2H, J=8 Hz), 7.60 (d, 2H, J=8.4 Hz), 7.32 (d, 2H, J=8.4 Hz), 7.02 (s, 1H), 6.52 (s, 1H), 4.70 (s, 2H), 4.03 (s, 2H), 3.73 (s, 3H), 2.00 (s, 3H). MS m/z 463 (M+1). Anal. Calc'd for C24H21F3NO4S.0.1 H2O C, 62.09; H, 4.60. found: C, 62.00; H, 4.36.

Sources & evidence

ORD record
ord-3a93d08b1b164f3eb2ce1a69ea44313e
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

Loading…