[4-(4'-Chloro-3'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester → [4-(4'-Chloro-3'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic acid

HRID 1063662Notes

Reaction equation

HRID 1063662 reaction equation
ClC1C=CC(C2C=CC(CO)=CC=2)=CC=1C(F)(F)F.C[O:21][C:22](=[O:51])[CH2:23][O:24][C:25]1[CH:30]=[CH:29][C:28]([S:31][CH2:32][C:33]2[CH:38]=[CH:37][C:36]([C:39]3[CH:44]=[CH:43][C:42]([Cl:45])=[C:41]([C:46]([F:49])([F:48])[F:47])[CH:40]=3)=[CH:35][CH:34]=2)=[CH:27][C:26]=1[CH3:50]>>[Cl:45][C:42]1[CH:43]=[CH:44][C:39]([C:36]2[CH:37]=[CH:38][C:33]([CH2:32][S:31][C:28]3[CH:29]=[CH:30][C:25]([O:24][CH2:23][C:22]([OH:51])=[O:21])=[C:26]([CH3:50])[CH:27]=3)=[CH:34][CH:35]=2)=[CH:40][C:41]=1[C:46]([F:49])([F:47])[F:48]

Participants

3

Reactant 2

HCID 20827025[4-(4'-Chloro-3'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester2×HCID 22280030(4'-Chloro-3'-trifluoromethyl-biphenyl-4-yl)-methanol

Product 1

HCID 22280076[4-(4'-Chloro-3'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic acid

Procedure

The title compound was prepared in the manner analogous to Example 3B using 6A. MS m/z 305 (M). Step 3. Preparation of [4-(4′-Chloro-3′-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-2-methyl-phenoxy]-acetic acid methyl ester (Compound 6C)

Sources & evidence

ORD record
ord-3ae0dd50fe524ed7a4bcc67636815a2e
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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