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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1063689Generated: November 2, 2026

[5-Methoxy-2-methyl-4-(3-methyl-4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid methyl ester → [5-Methoxy-2-methyl-4-(3-methyl-4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

https://huagongshe.com/reaction/1063689

Reaction equation

Participants

RoleNameHCIDCharge
Reactant[5-Methoxy-2-methyl-4-(3-methyl-4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid methyl esterHCID 20827046—
Reactant[3-Methyl-4'-(trifluoromethyl)biphenyl-4-yl]methanolHCID 22280004—
Product[5-Methoxy-2-methyl-4-(3-methyl-4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acidHCID 10288768—

Reaction Steps

The title compound was prepared in the manner analogous to Example 3B using 39A. 400 MHz 1H NMR (DMSO-d6) δ 7.84 (d, 2H, J=8.3 Hz), 7.76 (d, 2H, J=8.3 Hz), 7.57 (s, 1H), 7.48 (m, 2H), 4.80 (s, 2H), 2.41 (s, 3H). Step 3. Preparation of [5-Methoxy-2-methyl-4-(3-methyl-4′-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid methyl ester (Compound 39C)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06964983B2
Source datasetuspto-grants-2005_11
ORD IDord-8471bcf411394e7095a627b8784ca004
Source noteuspto-grants-2005_11