Thionyl Chloride → {7-[4-(4-Trifluoromethyl-benzyl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid

Participants

Role	Name	HCID	Charge
Reactant	Thionyl Chloride	HCID 24386	—
Reactant	4-(4-Trifluoromethylphenyl)benzylchloride	HCID 11459921	—
Reactant	{7-[4-(4-Trifluoromethyl-benzyl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester	HCID 20827092	—
Reactant	[4-(4-Trifluoromethyl-benzyl)-phenyl]-methanol	HCID 22280156	—
Product	{7-[4-(4-Trifluoromethyl-benzyl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid	HCID 22280029	—

Reaction Steps

The title compound was prepared in a similar manner as described for 3B using 40B and thionyl chloride. 400 MHz 1H NMR (DMSO-d6) 7.59 (d, 2H, J=8.4 Hz), 7.40 (d, 2H, J=8.4 Hz), 7.31 (d, 2H, J=8.4 Hz), 7.20 (d, 2H, J=8.4 Hz), 4.67 (s, 2H), 3.99 (s, 2H). Step 4. Preparation of {7-[4-(4-Trifluoromethyl-benzyl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester (Compound 40D)

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US06964983B2
Source dataset	uspto-grants-2005_11
ORD ID	ord-829976cdda7244e4bf94e99ccbca4fa2
Source note	uspto-grants-2005_11