{7-[4-(4-Trifluoromethyl-benzyl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester → HCID 22280029, compound

HRID 1063693Notes

Reaction equation

HRID 1063693 reaction equation
C[O:2][C:3](=[O:34])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([S:15][CH2:16][C:17]2[CH:22]=[CH:21][C:20]([CH2:23][C:24]3[CH:29]=[CH:28][C:27]([C:30]([F:33])([F:32])[F:31])=[CH:26][CH:25]=3)=[CH:19][CH:18]=2)=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2>O>[F:32][C:30]([F:31])([F:33])[C:27]1[CH:28]=[CH:29][C:24]([CH2:23][C:20]2[CH:19]=[CH:18][C:17]([CH2:16][S:15][C:12]3[CH:13]=[CH:14][C:6]([O:5][CH2:4][C:3]([OH:34])=[O:2])=[C:7]4[C:11]=3[CH2:10][CH2:9][CH2:8]4)=[CH:22][CH:21]=2)=[CH:25][CH:26]=1

Participants

3

Reactant 1

HCID 20827092{7-[4-(4-Trifluoromethyl-benzyl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester

Product 1

HCID 22280029HCID 22280029, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

The title compound was prepared in the manner analogous to Example 1 using 40D. IR cm−1:1745, 1704, 1325; 400 MHz 1H NMR (DMSO-d6) δ 7.58 (d, 2H, J=8.1 Hz), 7.37 (d, 2H, J=8.1 Hz), 7.09 (s, 2H), 7.05 (d, 2H, J=8.3 Hz), 6.55 (d, 1H, J=8.3 Hz), 4.60 (s, 2H), 3.94 (s, 4H), 2.71 (t, 2H, J=8.3 Hz), 2.58 (t, 2H, J=8.3 Hz), 1.81 (m, 2H); MS m/z 473 (M+1). Anal. Calc'd for C26H23F3O3S.0.1 H2O, C, 65.84; H, 4.93. found: C, 65.58; H, 4.96.

Sources & evidence

ORD record
ord-6f881053d87a4868ac764fe03f02b2f5
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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