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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1063700Generated: November 2, 2026

4'-(Trifluoromethyl)[1,1'-biphenyl]-3-methanol → [7-(4'-Trifluoromethyl-biphenyl-3-ylmethylsulfanyl)-indan-4-yloxy]-acetic Acid

https://huagongshe.com/reaction/1063700

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4'-(Trifluoromethyl)[1,1'-biphenyl]-3-methanolHCID 14468003—
Reactant[7-(4'-Trifluoromethyl-biphenyl-3-ylmethylsulfanyl)-indan-4-yloxy]-acetic acid methyl esterHCID 20827075—
Product[7-(4'-Trifluoromethyl-biphenyl-3-ylmethylsulfanyl)-indan-4-yloxy]-acetic AcidHCID 22280056—

Reaction Steps

The title compound was prepared in the manner analogous to Example 3B using 48A. MS m/z 236 (M+1-Cl). Step 3. Preparation of [7-(4′-Trifluoromethyl-biphenyl-3-ylmethylsulfanyl)-indan-4-yloxy]-acetic acid methyl ester (Compound 48C)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06964983B2
Source datasetuspto-grants-2005_11
ORD IDord-f780a82d8fff4ee7b8b4cdba02318bf0
Source noteuspto-grants-2005_11