2-Propylphenol → [2-Propyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

HRID 1063703Notes

Reaction equation

HRID 1063703 reaction equation
ClC[C:3]1[CH:4]=[C:5]([C:9]2[CH:14]=[CH:13][C:12]([C:15]([F:18])([F:17])[F:16])=[CH:11][CH:10]=2)[CH:6]=[CH:7][CH:8]=1.C[O:20][C:21](=[O:34])[CH2:22][O:23][C:24]1[CH:29]=[CH:28][C:27]([SH:30])=[CH:26][C:25]=1[CH2:31][CH2:32][CH3:33].[CH2:35](C1C=CC=CC=1O)CC>>[CH2:31]([C:25]1[CH:26]=[C:27]([S:30][CH2:35][C:8]2[CH:3]=[CH:4][C:5]([C:9]3[CH:10]=[CH:11][C:12]([C:15]([F:16])([F:17])[F:18])=[CH:13][CH:14]=3)=[CH:6][CH:7]=2)[CH:28]=[CH:29][C:24]=1[O:23][CH2:22][C:21]([OH:20])=[O:34])[CH2:32][CH3:33]

Participants

4

Reactant 3

HCID 125702-PropylphenolHCID 222801383-(4-Trifluoromethylphenyl)-benzyl chlorideHCID 69472858(4-Mercapto-2-propyl-phenoxy)-acetic acid methyl ester

Product 1

HCID 22280147[2-Propyl-4-(4'-trifluoromethyl-biphenyl-4-ylmethylsulfanyl)-phenoxy]-acetic acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using 48B and (4-Mercapto-2-propyl-phenoxy)-acetic acid methyl ester, prepared from 2-propylphenol in a manner analagous to Example 2. MS m/z 475 (M+1).

Sources & evidence

ORD record
ord-9e3f5fdb05c6447cbe86c221ad90af4c
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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