{7-[3-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester → {7-[3-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid

HRID 1063704Notes

Reaction equation

HRID 1063704 reaction equation
FC(F)(F)C1C=CC(C2C=C(CO)C=CC=2)=NC=1.C[O:20][C:21](=[O:51])[CH2:22][O:23][C:24]1[CH:32]=[CH:31][C:30]([S:33][CH2:34][C:35]2[CH:40]=[CH:39][CH:38]=[C:37]([C:41]3[CH:46]=[CH:45][C:44]([C:47]([F:50])([F:49])[F:48])=[CH:43][N:42]=3)[CH:36]=2)=[C:29]2[C:25]=1[CH2:26][CH2:27][CH2:28]2>>[F:50][C:47]([F:48])([F:49])[C:44]1[CH:45]=[CH:46][C:41]([C:37]2[CH:36]=[C:35]([CH:40]=[CH:39][CH:38]=2)[CH2:34][S:33][C:30]2[CH:31]=[CH:32][C:24]([O:23][CH2:22][C:21]([OH:51])=[O:20])=[C:25]3[C:29]=2[CH2:28][CH2:27][CH2:26]3)=[N:42][CH:43]=1

Participants

3

Reactant 2

HCID 20827077{7-[3-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester2×HCID 222800643-(3-(Trifluoromethyl)pyridin-2-YL)benzyl alcohol

Product 1

HCID 22280108{7-[3-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid

Procedure

The title compound was prepared in the manner analogous to Example 3B using 53A. MS m/z 237 (M+1-Cl). Step 3. Preparation of {7-[3-(5-Trifluoromethyl-pyridin-2-yl)-benzylsulfanyl]-indan-4-yloxy}-acetic acid methyl ester (Compound 53C)

Sources & evidence

ORD record
ord-f41f534dfe3c4558be1dab82a2882a15
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

Loading…