4-Hydroxybenzyl Alcohol → HCID 22280176, compound

HRID 1063714Notes

Reaction equation

HRID 1063714 reaction equation
C[O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([SH:15])=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2.Cl[CH2:18][C:19]1(F)[CH:24]=[CH:23][C:22]([O:25][CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)=[CH:21][CH2:20]1.OCC1C=CC(O)=CC=1.BrCC1C=C[C:48]([F:51])=CC=1.ClCC1(C(F)(F)F)C=CC(OCC2C=CC=CC=2)=CC1>>[F:51][CH2:48][C:30]1[CH:31]=[CH:32][C:27]([CH2:26][O:25][C:22]2[CH:23]=[CH:24][C:19]([CH2:18][S:15][C:12]3[CH:13]=[CH:14][C:6]([O:5][CH2:4][C:3]([OH:2])=[O:16])=[C:7]4[C:11]=3[CH2:10][CH2:9][CH2:8]4)=[CH:20][CH:21]=2)=[CH:28][CH:29]=1

Participants

6

Reactant 5

HCID 1254-Hydroxybenzyl AlcoholHCID 680214-Fluorobenzyl bromideHCID 20770872(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl EsterHCID 694705984-Chloromethyl-(4-trifluoromethyl-benzyloxy-benzene)HCID 694706064-Chloromethyl-(4-fluoro-benzyloxy-benzene)

Product 1

HCID 22280176HCID 22280176, compound

Procedure

The title compound was prepared in the manner analogous to Example 1F using 12C and 4-chloromethyl-(4-fluoro-benzyloxy-benzene), prepared from 4-hydroxymethyl-phenol and 1-bromomethyl-4-fluoro-benzene in a manner analagous to Examples 14A and 14B. MS m/z 453 (M+1).

Sources & evidence

ORD record
ord-cda9ec811f5d4e809ba3c819f559e77c
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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