4-Hydroxybenzyl Alcohol → {7-[4-(2,5-Dichloro-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic acid

HRID 1063724Notes

Reaction equation

HRID 1063724 reaction equation
C[O:2][C:3](=[O:16])[CH2:4][O:5][C:6]1[CH:14]=[CH:13][C:12]([SH:15])=[C:11]2[C:7]=1[CH2:8][CH2:9][CH2:10]2.[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=1[CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([CH2:33]Cl)=[CH:29][CH:28]=1.ClC1C=CC(Cl)=CC=1CCl.OCC1C=CC(O)=CC=1.ClCC1(C(F)(F)F)C=CC(OCC2C=CC=CC=2)=CC1>>[Cl:17][C:18]1[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][C:19]=1[CH2:25][O:26][C:27]1[CH:28]=[CH:29][C:30]([CH2:33][S:15][C:12]2[CH:13]=[CH:14][C:6]([O:5][CH2:4][C:3]([OH:2])=[O:16])=[C:7]3[C:11]=2[CH2:10][CH2:9][CH2:8]3)=[CH:31][CH:32]=1

Participants

6

Reactant 5

HCID 1254-Hydroxybenzyl AlcoholHCID 759762,5-Dichlorobenzyl chlorideHCID 20770872(7-Mercapto-indan-4-yloxy)-acetic Acid Methyl EsterHCID 222800501,4-Dichloro-2-(4-chloromethyl-phenoxymethyl)-benzeneHCID 694705984-Chloromethyl-(4-trifluoromethyl-benzyloxy-benzene)

Product 1

HCID 22280187{7-[4-(2,5-Dichloro-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using 12C and 1,4-Dichloro-2-(4-chloromethyl-phenoxymethyl)-benzene prepared from 1,4-dichloro-2-chloromethyl-benzene and 4-hydroxymethyl-phenol in the manner analagous to Examples 14A and 14B. MS m/z 265 (M−237).

Sources & evidence

ORD record
ord-21f0493bce2a432e81a9ae58105f10c3
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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