HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzyl Alcohol → {7-[4-(4-Chloro-3-trifluoromethyl-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzyl Alcohol | HCID 125 | — |
| Reactant | 4-Chloro-3-(trifluoromethyl)benzyl bromide | HCID 2778114 | — |
| Reactant | (7-Mercapto-indan-4-yloxy)-acetic Acid Methyl Ester | HCID 20770872 | — |
| Reactant | 1-Chloro-4-(4-chloromethyl-phenoxymethyl)-2-trifluoromethyl-benzene | HCID 22280128 | — |
| Reactant | 4-Chloromethyl-(4-trifluoromethyl-benzyloxy-benzene) | HCID 69470598 | — |
| Product | {7-[4-(4-Chloro-3-trifluoromethyl-benzyloxy)-benzylsulfanyl]-indan-4-yloxy}-acetic Acid | HCID 22280125 | — |
Reaction Steps
The title compound was prepared in the manner analogous to Example 1F using 12C and 1-Chloro-4-(4-chloromethyl-phenoxymethyl)-2-trifluoromethyl-benzene prepared from 1-bromomethyl-4-chloro-3-trifluoromethyl-benzene and 4-hydroxymethyl-phenol in the manner analagous to Examples 14A and 14B. MS m/z 299 (M−237).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06964983B2 |
| Source dataset | uspto-grants-2005_11 |
| ORD ID | ord-614c99308a7c40f09a0483756d9751a5 |
| Source note | uspto-grants-2005_11 |