(8-Mercapto-chroman-5-yloxy)-acetic acid methyl ester → {8-[3-(4-Trifluoromethyl-benzyloxy)-benzylsulfanyl]-chroman-5-yloxy}-acetic acid

HRID 1063746Notes

Reaction equation

HRID 1063746 reaction equation
C[O:2][C:3](=[O:17])[CH2:4][O:5][C:6]1[CH:15]=[CH:14][C:13]([SH:16])=[C:12]2[C:7]=1[CH2:8][CH2:9][CH2:10][O:11]2.[F:18][C:19]([F:37])([F:36])[C:20]1[CH:35]=[CH:34][C:23]([CH2:24][O:25][C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([CH2:32]Cl)[CH:27]=2)=[CH:22][CH:21]=1>>[F:18][C:19]([F:36])([F:37])[C:20]1[CH:35]=[CH:34][C:23]([CH2:24][O:25][C:26]2[CH:27]=[C:28]([CH:29]=[CH:30][CH:31]=2)[CH2:32][S:16][C:13]2[CH:14]=[CH:15][C:6]([O:5][CH2:4][C:3]([OH:2])=[O:17])=[C:7]3[C:12]=2[O:11][CH2:10][CH2:9][CH2:8]3)=[CH:22][CH:21]=1

Participants

3

Reactant 2

HCID 11288267(8-Mercapto-chroman-5-yloxy)-acetic acid methyl esterHCID 22280116HCID 22280116, compound

Product 1

HCID 22280110{8-[3-(4-Trifluoromethyl-benzyloxy)-benzylsulfanyl]-chroman-5-yloxy}-acetic acid

Procedure

The title compound was prepared in the manner analogous to Example 1F using (8-mercapto-chroman-5-yloxy)-acetic acid methyl ester and 79B. MS m/z 519 (M+1).

Sources & evidence

ORD record
ord-3d29066143fe4dd9a6836c0eef47ea21
Source dataset
uspto-grants-2005_11
Patent number
US06964983B2

Reaction notes

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