Phosphorus tribromide → 2-[2-butyl-4-({4-[4-(trifluoromethyl)phenyl]phenyl}methylthio)phenoxy]acetic Acid

HRID 1063764Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1063764
[CH2:1]([C:5]1[CH:16]=[C:15]([SH:17])[CH:14]=[CH:13][C:6]=1[O:7][CH2:8][C:9]([O:11]C)=[O:10])[CH2:2][CH2:3][CH3:4].Br[CH2:19][C:20]1[CH:25]=[CH:24][C:23]([C:26]2[CH:31]=[CH:30][C:29]([C:32]([F:35])([F:34])[F:33])=[CH:28][CH:27]=2)=[CH:22][CH:21]=1.P(Br)(Br)Br.FC(F)(F)C1C=CC(C2C=CC(CO)=CC=2)=CC=1>>[CH2:1]([C:5]1[CH:16]=[C:15]([S:17][CH2:19][C:20]2[CH:21]=[CH:22][C:23]([C:26]3[CH:31]=[CH:30][C:29]([C:32]([F:33])([F:34])[F:35])=[CH:28][CH:27]=3)=[CH:24][CH:25]=2)[CH:14]=[CH:13][C:6]=1[O:7][CH2:8][C:9]([OH:11])=[O:10])[CH2:2][CH2:3][CH3:4]

Komponenten

5

Edukt 4

HCID 24614Phosphorus tribromideHCID 22015014(4'-(Trifluoromethyl)-[1,1'-biphenyl]-4-yl)methanolHCID 22280099Methyl 2-(2-butyl-4-sulfanylphenoxy)acetateHCID 222801654-(Bromomethyl)-4'-(trifluoromethyl)-1,1'-biphenyl

Produkt 1

HCID 222801432-[2-butyl-4-({4-[4-(trifluoromethyl)phenyl]phenyl}methylthio)phenoxy]acetic Acid

Versuchsvorschrift

The title compound was prepared in the manner analogous to Example 1F using 100F and 1-(bromomethyl)-4-[4-(trifluoromethyl)phenyl]benzene prepared from and phosphorous tribromide and (4′-trifluoromethyl-biphenyl-4-yl)-methanol in a manner analagous to Example 3B. 400 MHz 1H NMR (CDCl3) δ 7.68 (m, 4H), 7.51 (d, 2H), 7.29 (d, 2H), 7.15 (m, 2H), 6.60 (d, 1H), 4.62 (s, 2H), 4.04 (s, 2H), 3.79 (s, 3H), 2.60 (m, 2H), 1.55 (m, 2H), 1.35 (m, 2H), 0.88 (t, 3H).

Quellen und Nachweise

ORD-Eintrag
ord-5c19270350ae4497941687c747f82ddb
Quelldatensatz
uspto-grants-2005_11
Patentnummer
US06964983B2

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