Dimethylformamide → HCID 23402490, compound

HRID 1063812Notes

Reaction equation

HRID 1063812 reaction equation
[C:1](Cl)(=O)[C:2](Cl)=O.[CH:7]([C:10]1[NH:14][N:13]=[C:12]([C:15]([OH:17])=O)[C:11]=1[N+:18]([O-:20])=[O:19])([CH3:9])[CH3:8].C[N:22](C)C=O>ClCCl>[CH:7]1([C:10]2[NH:14][N:13]=[C:12]([C:15]([NH2:22])=[O:17])[C:11]=2[N+:18]([O-:20])=[O:19])[CH2:8][CH2:2][CH2:1][CH2:9]1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 65578Oxalyl chlorideHCID 121506014-nitro-5-(propan-2-yl)-1H-pyrazole-3-carboxylic acid

Product 1

HCID 23402490HCID 23402490, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

Oxalyl chloride (7.65 ml, 87.7 mmol) was added dropwise to a suspension of 5-isopropyl-4-nitro-1H-pyrazol-3-carboxylic acid (6.58 g, 29.2 mmol) in dichloromethane (100 ml) containing dimethylformamide (0.5 ml) under nitrogen at 0° C. The reaction was stirred at 0° C. for 1 hours, allowed to warm to room temperature and stirred for a further 2 hours. The solvent was removed under reduced pressure, the residue was azeotroped with dichloromethane (2×50 ml) and dissolved in toluene (100 ml). Ammonia gas was bubbled into the solution for 2 hours and the reaction was stirred under nitrogen at room temperature for 18 hours, concentrated under reduced pressure and purified by flash column chromatography on silica gel eluting with a solvent gradient of dichloromethane:methanol (95:5 changing to 90:10, by volume) to give 5-cyclopentyl-4-nitro-1H-pyrazol-3-carboxylic acid amide (5.48 g) as a yellow solid. 1H NMR (400 MHz, DMSO-D6): δ=13.67-13.79 (1H, brs), 7.88-8.03 (1H, brs), 7.59-7.77 (1H, brs), 3.46-3.60 (1H, quin), 1.97-2.11 (2H, m), 1.58-1.81 (6H, 2×m) ppm. LRMS (electrospray): m/z [M−H]+ 223, [2M−H]+ 447. Anal. Found C, 56.12; H, 7.39; N, 27.55. C9H12N4O3. 0.2 mol acetone requires C, 56.01; H, 7.44; N, 27.22%.

Workup

  1. temperatureto warm to room temperature
  2. stirringstirred for a further 2 hours
  3. customThe solvent was removed under reduced pressure
  4. customthe residue was azeotroped with dichloromethane (2×50 ml)
  5. dissolutiondissolved in toluene (100 ml)
  6. customAmmonia gas was bubbled into the solution for 2 hours
  7. stirringthe reaction was stirred under nitrogen at room temperature for 18 hours
  8. concentrationconcentrated under reduced pressure
  9. custompurified by flash column chromatography on silica gel eluting with a solvent gradient of dichloromethane:methanol (95:5 changing to 90:10, by volume)

Sources & evidence

ORD record
ord-acc254a9391d4ba69b3988da53007b36
Source dataset
uspto-grants-2005_11
Patent number
US06967204B2

Reaction notes

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