HCID 13569175, compound → HCID 13569189, compound

Participants

Reaction Steps

[2-(2-Imidazol-1-yl-ethoxy)-phenyl]-acetic acid ethyl ester (3.5 g, 113 mmol) was stirred in 50% aqueous hydrochloric acid (20 ml) at 100° C. for 6 hours. After cooling to room temperature the solvent was removed under reduced pressure and the residue was recrystallised from isopropylalcohol to give [2-(2-Imidazol-1-yl-ethoxy)-phenyl]-acetic acid (2.73 g) as a white solid. Mp 146-147° C. νmax (thin film) 3410 (O—H), 1722 cm−1 (C═O, acid). Anal. Found C, 54.89; H, 5.25; N, 9.80. C13H14N2O3. 1 mol HCl requires C, 55.22; H, 5.35; N, 9.91%.

Provenance & Evidence