Ammonium Chloride → HCID 23402381, compound

HRID 1063859Notes

Reaction equation

HRID 1063859 reaction equation
CC1C2C=COC=2C(Br)=CC=1F.C[C@H]1CNCCN1.[CH3:20][C:21]1[C:26]2[CH:27]=[C:28]([F:30])[O:29][C:25]=2[C:24]([N:31]2[CH2:36][CH2:35][NH:34][C@@H:33]([CH3:37])[CH2:32]2)=[CH:23][C:22]=1[F:38].[Cl-:39].[NH4+]>CO>[ClH:39].[CH3:20][C:21]1[C:26]2[CH:27]=[C:28]([F:30])[O:29][C:25]=2[C:24]([N:31]2[CH2:36][CH2:35][NH:34][C@@H:33]([CH3:37])[CH2:32]2)=[CH:23][C:22]=1[F:38]

Participants

6

Reactant 4

HCID 25517Ammonium ChlorideHCID 27342192-Methylpiperazine, (S)-HCID 22277380HCID 22277380, compoundHCID 23402382HCID 23402382, compound

Product 1

HCID 23402381HCID 23402381, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Beginning with 4-methyl-5-fluoro-7-bromobenzofuran and 2(S)-methylpiperazine, 1-(4-methyl-5-fluorofluorobenzofur-7-yl)-3(S)-methylpiperazine was prepared as described. A solution of this material in methanol was treated with a methanolic solution containing one equivalent of ammonium chloride. The mixture was slowly concentrated under reduced pressure. The residue was triturated with diethyl ether and the solid collected by filtration to provide the title compound.

Workup

  1. customwas prepared
  2. concentrationThe mixture was slowly concentrated under reduced pressure
  3. customThe residue was triturated with diethyl ether
  4. filtrationthe solid collected by filtration

Sources & evidence

ORD record
ord-e57693e50d884911a2b649ca696e509e
Source dataset
uspto-grants-2005_11
Patent number
US06967201B1

Reaction notes

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