tert-Butyl piperazine-1-carboxylate → HCID 22277394, compound

HRID 1063864Notes

Reaction equation

HRID 1063864 reaction equation
[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[C:12](Br)[C:13]2[O:17][CH:16]=[CH:15][C:14]=2[CH:18]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2].[C:20]([O:24][C:25]([N:27]1[CH2:32][CH2:31][NH:30][CH2:29][CH2:28]1)=[O:26])([CH3:23])([CH3:22])[CH3:21]>>[Si:1]([O:8][CH2:9][C:10]1[CH:11]=[C:12]([N:30]2[CH2:29][CH2:28][N:27]([C:25]([O:24][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:26])[CH2:32][CH2:31]2)[C:13]2[O:17][CH:16]=[CH:15][C:14]=2[CH:18]=1)([C:4]([CH3:7])([CH3:6])[CH3:5])([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 143452tert-Butyl piperazine-1-carboxylateHCID 22144737HCID 22144737, compound

Product 1

HCID 22277394HCID 22277394, compoundYield 63%

Procedure

Beginning with 0.51 gm (1.5 mMol) 5-(tert-butyldimethylsilyloxymethyl)-7-bromobenzofuran and 0.30 gm (1.6 mMol) 1-tert-butoxycarbonylpiperazine, 0.42 gm (63%) of the desired compound were prepared essentially as described in GENERAL PROCEDURE II.

Sources & evidence

ORD record
ord-e9ba55a7b28546ecb759b0f9f0c2e646
Source dataset
uspto-grants-2005_11
Patent number
US06967201B1

Reaction notes

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