Methanol → HCID 22276508, compound

Participants

Reaction Steps

To a solution of 2-aminoethanethiol (37.5 g) and sodium hydroxide (15 g) in methanol (500 ml) was added a solution of ethyl 3-(5-bromo-2-thienylacrylate (97.7 g) in methanol (500 ml) under ice-cooling and a nitrogen atmosphere. After being stirred at room temperature for 3 days, the resulting precipitate was collected by filtration and washed with methanol (MeOH) to afford 7-(5-bromo-2-thienyl)perhydro-1,4-thiazepin-5-one (84.6 g) as a solid.

Provenance & Evidence