HCID 69745341, compound → HCID 69746573, compound

HRID 1063913Notes

Reaction equation

HRID 1063913 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[S:13][C:12]([C@:14]3([CH2:29][C:30]([O:32]C(C)(C)C)=[O:31])[S:20](=[O:22])(=[O:21])[CH2:19][CH2:18][N:17]([S:23]([CH2:26][CH2:27][CH3:28])(=[O:25])=[O:24])[CH2:16][CH2:15]3)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1)[CH3:2]>C(O)=O>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[S:13][C:12]([C@:14]3([CH2:29][C:30]([OH:32])=[O:31])[S:20](=[O:21])(=[O:22])[CH2:19][CH2:18][N:17]([S:23]([CH2:26][CH2:27][CH3:28])(=[O:25])=[O:24])[CH2:16][CH2:15]3)=[CH:11][CH:10]=2)=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 1

HCID 69745341HCID 69745341, compound

Product 1

HCID 69746573HCID 69746573, compoundYield 108.9%

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

A solution of tert-butyl 2-[(S)-7-[5-(4-ethylphenyl)-2-thienyl]-1,1-dioxoperhydro-4-propanesulfonyl-1,4-thiazepin-7-yl]acetate (4.70 g) in formic acid (50 ml) was stirred for 2 hours at room temperature. The volatile was removed in vacuo and three evaporation from chloroform (30 ml) afforded 2-[((S)-7-[5-(4-ethylphenyl)-2-thienyl]-1,1-dioxoperhydro-4-propanesulfonyl-1,4-thiazepin-7-yl]acetic acid (4.60 g) as a pale yellow solid.

Workup

  1. customThe volatile was removed in vacuo and three evaporation from chloroform (30 ml)

Sources & evidence

ORD record
ord-d6f83df20ab54ee38f169541c2209812
Source dataset
uspto-grants-2005_11
Patent number
US06967197B2

Reaction notes

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