Phosphorus pentachloride → HCID 54444968, compound

HRID 1063949Notes

Reaction equation

[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:28])=[C:6]([N:8]([S:18]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)(=[O:20])=[O:19])[C@H:9]([CH3:17])[CH2:10][CH2:11][CH2:12][S:13](O)(=[O:15])=[O:14])[CH:7]=1.P(Cl)(Cl)(Cl)(Cl)[Cl:30]>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([F:28])=[C:6]([N:8]([S:18]([C:21]2[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=2)(=[O:20])=[O:19])[C@H:9]([CH3:17])[CH2:10][CH2:11][CH2:12][S:13]([Cl:30])(=[O:15])=[O:14])[CH:7]=1

Participants

Reactant 2

HCID 24819Phosphorus pentachloride

HCID 54034892HCID 54034892, compound

Product 1

HCID 54444968HCID 54444968, compoundYield 81%

Procedure

(4R)-4-[N-[5-chloro-2-fluorophenyl][(4-chlorophenyl)sulfonyl]amino]pentylsulfonyl chloride was prepared analogous to (4R)-4-[N-[2,5-dichlororophenyl][(4-chlorophenyl)sulfonyl]amino]pentyl-sulfonyl chloride by reacting (4R)-4-[N-[5-chloro-2-fluorophenyl][(4-chlorophenyl)sulfonyl]amino]-pentylsulfonic acid with phosphorus pentachloride: Yield=81%; MS (ESI) 489 (+1).

Sources & evidence

ORD record: ord-0b869cb6702e4ddba98e0d0c6f412e3e
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06967196B1

Reaction notes

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