Phosphorus pentachloride → HCID 53996712, compound

HRID 1063955Notes

Reaction equation

HRID 1063955 reaction equation
[CH2:1]([S:6]([Cl:9])(=[O:8])=[O:7])[CH2:2][CH2:3][CH2:4][CH3:5].[F:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[N:18]([S:28]([C:31]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=1)(=[O:30])=[O:29])[C@H](C)CCCS(O)(=O)=O.P(Cl)(Cl)(Cl)(Cl)Cl>>[F:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][C:12]=1[N:18]([S:28]([C:31]1[CH:36]=[CH:35][C:34]([Cl:37])=[CH:33][CH:32]=1)(=[O:30])=[O:29])[C@H:4]([CH3:5])[CH2:3][CH2:2][CH2:1][S:6]([Cl:9])(=[O:8])=[O:7]

Participants

4

Reactant 3

HCID 24819Phosphorus pentachlorideHCID 2375551-Pentanesulfonyl chlorideHCID 54303834HCID 54303834, compound

Product 1

HCID 53996712HCID 53996712, compoundYield 88%

Procedure

(4R)-4-[N-[2,5-difluorophenyl][(4-chlorophenyl)sulfonyl]amino]pentylsulfonyl chloride was prepared analogous to (4R)-4-[2,5-dichlorophenyl][4-chlorophenyl)sulfonyl]-amino]pentylsulfonyl chloride by reacting (4R)-4-[N-[2,5-difluorophenyl][(4-chlorophenyl)sulfonyl]amino]pentylsulfonic acid with phosphorus pentachloride. Yield=88%; MS (ESI) 434 (M+1).

Sources & evidence

ORD record
ord-31afa48c853b4a8da187b963d6a05d11
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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