Methanesulfonamide → HCID 23401735, compound

HRID 1063967Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C:18]2[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=2[F:25])[C@H:12]([CH3:17])[CH2:13][CH2:14][CH2:15]Br)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH3:26][S:27]([NH2:30])(=[O:29])=[O:28]>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C:18]2[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=2[F:25])[C@H:12]([CH3:17])[CH2:13][CH2:14][CH2:15][NH:30][S:27]([CH3:26])(=[O:29])=[O:28])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 72879Methanesulfonamide

HCID 23401732HCID 23401732, compound

Product 1

HCID 23401735HCID 23401735, compoundYield 89%

Procedure

4-chloro-N-(5-chloro-2-fluorophenyl)-N-[4-[(methylsulfonyl)amino]-1(R)-methylbutyl]-benzenesulfonamide was prepared analogous to 4-chloro-N-(2,5-dichlorophenyl)-N-[4-[[4 (methylsulfonyl)methyl]-1-piperidinyl]-1(R)-methylbutyl]benzenesulfonamide by reacting 4-chloro-N-(5-chloro-2-fluorophenyl)-N-[4-bromo-1(R)-methylbutyl]benzenesulfonamide with methanesulfonamide. Yield=89%; MS (ESI+), 483 (M+H)+.

Sources & evidence

ORD record: ord-0ff03de05859448998b99c8dc800525a
Source dataset: uspto-grants-2005_11
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06967196B1

Reaction notes

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