Morpholine → HCID 23401731, compound

HRID 1063968Notes

Reaction equation

HRID 1063968 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C:18]2[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=2[F:25])[C@H:12]([CH3:17])[CH2:13][CH2:14][CH2:15]Br)(=[O:10])=[O:9])=[CH:4][CH:3]=1.[NH:26]1[CH2:31][CH2:30][O:29][CH2:28][CH2:27]1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C:18]2[CH:23]=[C:22]([Cl:24])[CH:21]=[CH:20][C:19]=2[F:25])[C@H:12]([CH3:17])[CH2:13][CH2:14][CH2:15][N:26]2[CH2:31][CH2:30][O:29][CH2:28][CH2:27]2)(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 8083MorpholineHCID 23401732HCID 23401732, compound

Product 1

HCID 23401731HCID 23401731, compoundYield 87%

Procedure

4-chloro-N-(5-chloro-2-fluorophenyl)-N-[4-(morpholinyl)-1(R)-methylbutyl]benzenesulfonamide was prepared analogous to 4-chloro-N-(2,5-dichlorophenyl)-N-[4-[[4-(methylsulfonyl)methyl]-1-piperidinyl]-1(R)-methylbutyl]benzenesulfonamide by reacting 4-chloro-N-(5-chloro-2-fluorophenyl)-N-[4-bromo-1(R)-methylbutyl]benzenesulfonamide with morpholine. Yield=87%; MS (ESI+), 475 (M+H)+.

Sources & evidence

ORD record
ord-c5099f8e35dc4ab783ab9744e8a5d921
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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