HCID 23401710, compound → Benzenesulfonamide

Participants

Reaction Conditions

Reaction Steps

To a solution of 4-chloro-N-(2,5-difluorophenyl)-N-[(R)-1-methyl-4-bromobutyl]benzenesulfonamide (0.194 g, 0.427 mmol) in ether (4 mL) was added AgNO2 (0.395 g, 2.56 mmol) at 22° C. The resulting mixture was allowed to stir at 22° C. for 4 days. The mixture was filtered and concentrated under reduced pressure. Silica gel chromatography (1:9 ethyl acetate:hexanes) of the concentrate afforded 0.0913 g of 4-chloro-N-(2,5-difluorophenyl)-N-[(R)-1-methyl-4-nitrobutyl]]-benzenesulfonamide as a light brown oil in 50% yield. MS (ESI) 419.1 (M+H).

Provenance & Evidence