Ethylamine → Benzenesulfonamide

HRID 1063981Notes

Reaction equation

HRID 1063981 reaction equation
Cl[C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11](C2C=C(Cl)C=CC=2Cl)[C@H](C)CCCS(NC)(=O)=O)(=[O:10])=[O:9])=[CH:4][CH:3]=1.C(S(Cl)(=O)=O)CCCC.C(N)C>>[C:5]1([S:8]([NH2:11])(=[O:10])=[O:9])[CH:6]=[CH:7][CH:2]=[CH:3][CH:4]=1

Participants

4

Reactant 3

HCID 6341EthylamineHCID 2375551-Pentanesulfonyl chlorideHCID 53796417HCID 53796417, compound

Product 1

HCID 7370BenzenesulfonamideYield 37%

Procedure

4-chloro-N-[2,5-dichlorophenyl]-N-[4-ethylaminosulfonyl)-1(R)-methylbutyl]benzenesulfonamide was prepared analogous to 4-chloro-N-[2,5-dichlorophenyl]-N-[4-[(methylamino)sulfonyl]-1(R)-methylbutyl]benzenesulfonamide by reacting (4R)-4-[2,5-dichlorophenyl][4-chlorophenyl)sulfonyl]-amino]pentylsulfonyl chloride with ethylamine. Yield=37%; MS (ESI+), 513 (M+H)+.

Sources & evidence

ORD record
ord-4d68f1fdda9c4a59a4afe3fca09a10ba
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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