Dimethylamine → HCID 23401688, compound

HRID 1063983Notes

Reaction equation

HRID 1063983 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C:22]2[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=2[Cl:29])[C@H:12]([CH3:21])[CH2:13][CH2:14][CH2:15][S:16]([NH:19][CH3:20])(=[O:18])=[O:17])(=[O:10])=[O:9])=[CH:4][CH:3]=1.[CH2:30](S(Cl)(=O)=O)CCCC.CNC>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([S:8]([N:11]([C:22]2[CH:27]=[C:26]([Cl:28])[CH:25]=[CH:24][C:23]=2[Cl:29])[C@H:12]([CH3:21])[CH2:13][CH2:14][CH2:15][S:16]([N:19]([CH3:30])[CH3:20])(=[O:17])=[O:18])(=[O:10])=[O:9])=[CH:4][CH:3]=1

Participants

4

Reactant 3

HCID 674DimethylamineHCID 2375551-Pentanesulfonyl chlorideHCID 53796417HCID 53796417, compound

Product 1

HCID 23401688HCID 23401688, compoundYield 65%

Procedure

4-chloro-N-[2,5-dichlorophenyl]-N-[4-(dimethylaminosulfonyl)-1(R)-methylbutyl]-benzenesulfonamide was prepared analogous to 4-chloro-N-[2,5-dichlorophenyl]-N-[4-[(methylamino)sulfonyl]-1(R)-methylbutyl]benzenesulfonamide by reacting (4R)-4-[2,5-dichlorophenyl][4-chlorophenyl)sulfonyl]-amino]pentylsulfonyl chloride with dimethylamine. Yield=65%; MS (ESI+), 513 (M+H)+.

Sources & evidence

ORD record
ord-b7c02942f4ac4c0fb8e987d0dafcd1ae
Source dataset
uspto-grants-2005_11
Patent number
US06967196B1

Reaction notes

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