Trifluoroacetic acid → HCID 22277815, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled solution (ice bath) of 1-{2-[N-methyl-N-(t-butoxycarbonyl)amino]ethyl}-1,2,4-triazole (Method 24; 1.6 g, 7.2 mmol) in DCM (10 ml) was added trifluoroacetic acid (5 ml). The reaction mixture was stirred for 3 hours at 0° C. and then at room temperature for 1 hour. The reaction mixture was evaporated to dryness with toluene and the crude product was dissolved in DCM (3 ml) and concentrated HCl in ether was added dropwise under vigorous stirring to yield the title compound as a white solid M/z 126.9.

Provenance & Evidence