4-(4-Chloro-phenyl)-5-pyridin-4-yl-pyrazolidin-3-one → HCID 10355853, compound

HRID 1064073Notes

Reaction equation

HRID 1064073 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]2[CH:12]([C:13]3[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=3)[NH:11][NH:10][C:9]2=[O:19])=[CH:4][CH:3]=1>C(O)C.[Pd]>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[C:9](=[O:19])[NH:10][NH:11][C:12]=2[C:13]2[CH:18]=[CH:17][N:16]=[CH:15][CH:14]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 1

HCID 222779894-(4-Chloro-phenyl)-5-pyridin-4-yl-pyrazolidin-3-one

Product 1

HCID 10355853HCID 10355853, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Conditions

Temperature
50 °C

Procedure

To solution of 4-(4-Chloro-phenyl)-5-pyridin-4-yl-pyrazolidin-3-one 20 mg in ethyl alcohol 5 mL was added Pd/C 1 mg. The reaction was heated to 50° C. for 48 hours, cooled to room temperature, filtered and concentrated to a solid. Purification by TLC plate followed by crystallization from chloroform and methanol give the title compound as an off-white solid. MS (ES+): 272 (M+H)+.

Workup

  1. temperaturecooled to room temperature
  2. filtrationfiltered
  3. concentrationconcentrated to a solid
  4. customPurification by TLC plate
  5. customfollowed by crystallization from chloroform and methanol

Sources & evidence

ORD record
ord-cb9818e9e2334c598a7620362332b37b
Source dataset
uspto-grants-2005_11
Patent number
US06967254B2

Reaction notes

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