HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1064081Generated: November 1, 2026
Hydrazine → 4-(3,4-Dichloro-phenyl)-5-pyridin-4-yl-pyrazolidin-3-one
https://huagongshe.com/reaction/1064081
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | 3-(3,4-Dichloro-phenyl)-2-oxo-4-pyridin-4-yl-but-3-enoic acid ethyl ester | HCID 69358895 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 4-(3,4-Dichloro-phenyl)-5-pyridin-4-yl-pyrazolidin-3-one | HCID 22277994 | — |
Reaction Steps
To a solution of 3-(3,4-Dichloro-phenyl)-2-oxo-4-pyridin-4-yl-but-3-enoic acid ethyl ester 11.4 g in ethyl alcohol 50 mL was added hydrazine 1.68 mL. The reaction was heated to 50° C. for 15 hours. All solvent was removed after under reduced pressure to afford the title compound 10.8 g as light yellow solid. MS (ES+): 308 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06967254B2 |
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| Source dataset | uspto-grants-2005_11 |
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| ORD ID | ord-959dee63bf01466fa3252518212c3a5f |
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| Source note | uspto-grants-2005_11 |
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