反应详情

The solution of 4-(3,4-Dichloro-phenyl)-1-isopropyl-5-pyridin-4-yl-pyrazolidin-3-one 90 mg in dichloromethane 10 mL was treated with phenyltriethylammonium tribromide 0.1 g at room temperature, The reaction mixture was stirred at room temperature for 15 h. The reaction was quenched with sat. Na2SO3 25 mL at 0° C. The reaction mixture was extracted with dichloromethane, 3×50 mL. The combined organic phase was washed with brine, dried over anhydrous Na2SO4. After purification by flash chromatography, the title compound was obtained as light yellow solid 45 mg. MS (ES+): 348 (M+H)+.

1. customThe reaction was quenched with sat. Na2SO3 25 mL at 0° C
2. extractionThe reaction mixture was extracted with dichloromethane, 3×50 mL
3. washThe combined organic phase was washed with brine
4. dry with materialdried over anhydrous Na2SO4
5. customAfter purification by flash chromatography