1,4-Dioxane → HCID 136401941, compound

Participants

Reaction Steps

Preparation of the title compound from Intermediate 146(a) (58 mg, 0.13 mmol) in CH2Cl2 (2 mL) and 4M HCl in dioxane (2 mL) was carried out analogously to Example 91. After concentration, the residue was purified by preparative HPLC (Peeke Scientific, HI-Q C18 reverse phase 5u, 100A, 250×21.2 mm column) eluting with CH3CN and 0.1% acetic acid in water at a flow rate of 20 mL/min using a gradient of 5-95% CH3CN over 40 min to give the title compound (16 mg, 0.04 mmol) as a pale yellow powder in 31% yield.

Provenance & Evidence