Lithium Hydroxide → HCID 21901285, compound

Participants

Reaction Steps

In a manner similar to that described for step 3 of Example 172, Intermediate 173(a) was treated with 1 M aqueous LiOH to give crude 2-[3-(4-methyl-piperazin-1-yl)-phenyl]-cyclopropanecarboxylic acid. Crude 2-[3-(4-methyl-piperazin-1-yl)-phenyl]-cyclopropanecarboxylic acid was coupled to the title compound of Example 2 (71 mg, 0.3 mmol) also in a manner similar to that described for step 3 of Example 172. Extractive work-up from ethyl acetate and saturated aqueous NaHCO3 afforded the crude product, which was purified by silica gel chromatography, eluting with 3% MeOH\CH2Cl2, to furnish the title compound (38 mg, 0.086 mmol) in 22% yield.

Provenance & Evidence