2,4-Difluorophenylboronic acid → HCID 10092720, compound

Participants

Reaction Steps

4,2′-Difluoro-5′-(3-methylsulfanyl-[1,2,4]triazin-5-yl)biphenyl-2-carbonitrile (0.15 g, 0.44 mmol) was coupled to 2,4-difluorobenzeneboronic acid (0.135 g, 0.97 mmol) by the method of Example 2 to give the title product as a pale yellow solid (124 mg): δH (400 MHz, CDCl3) 6.99-7.11 (2H, m), 7.44-7.48 (2H, m), 7.54-7.59 (2H, m), 8.32-8.39 (3H, m) 9.65 (1H, s); m/z (ES+) 407 (M++H).

Provenance & Evidence