2-Fluorophenylboronic acid → HCID 10318059, compound

Participants

Reaction Steps

4,2′-Difluoro-5′-(3-methylsulfanyl-[1,2,4]triazin-5-yl)biphenyl-2-carbonitrile (0.115 g, 0.338 mmol) was coupled to 2-fluorobenzeneboronic acid (0.104 g, 0.743 mmol) by the method of Example 2 to give the title product as a pale yellow solid (63 mg): 8H (400 MHz, CDCl3) 7.27 (1H, q, J 1.3 Hz), 7.32-7.37 (1H, m), 7.43-7.48 (2H, m), 7.53-7.60 (3H, m), 8.24-8.29 (1H, m), 8.35-8.39 (2H, m), 9.67 (1H, s); m/z(ES+) 389 (M++H).

Provenance & Evidence