5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine → 5-[3-(3,5-Difluoropyridin-4-yl)-4-fluorophenyl]-3-(2,4-difluorophenyl)-[1,2,4]triazine

Participants

Reaction Steps

5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine was coupled to 3,5-difluoro-4-tributylstannylpyridine using the method of Example 6 to give 5-[3-(3,5-difluoropyridin-4-yl)-4-fluorophenyl]-3-(2,4-difluorophenyl)-[1,2,4]triazine, crystallised from hot 2-propanol as a pale yellow solid: δH (500 MHz, d6-DMSO) 7.35 (1H, m), 7.52 (1H, m), 7.79 (1H, t, J 8.9 Hz), 8.34 (1H, m), 8.71 (2H, m), 8.79 (2H, s), 10.13 (1H, s); m/z (ES+) 401.

Provenance & Evidence