3-(Diethylboryl)pyridine → 5-[4-Fluoro-3-(pyridin-3-yl)phenyl]-3-methylsulfanyl-[1,2,4]triazine

Participants

Reaction Steps

5-(3-Bromo-4-fluorophenyl)-3-methylsulfanyl-[1,2,4]triazine was coupled to diethyl(3-pyridyl)borane by the method of Example 12 to give 5-[4-fluoro-3-(pyridin-3-yl)phenyl]-3-methylsulfanyl-[1,2,4]triazine as a yellow solid: δH (400 MHz, CDCl3) 2.74 (3H, s), 7.37-7.46 (2H, m), 7.91-7.95 (1H, m), 8.16-8.20 (1H, m), 8.30 (1H, dd, J 2.3, 7.4 Hz), 8.70 (1H, dd, J 1.4, 4.9 Hz), 8.86 (1H, s), 9.40 (1H, s); m/z (ES+) 299.

Provenance & Evidence