(4-Methoxyphenyl)boronic acid → 5-[4-Fluoro-3-(pyridin-3-yl)phenyl]-3-(4-methoxyphenyl)-[1,2,4]triazine

Participants

Reaction Steps

5-[4-Fluoro-3-(pyridin-3-yl)phenyl]-3-methylsulfanyl-[1,2,4]triazine was coupled to 4-methoxyphenylboronic acid by the method of Example 2 to give 5-[4-fluoro-3-(pyridin-3-yl)phenyl]-3-(4-methoxyphenyl)-[1,2,4]triazine as an orange solid: δH (400 MHz, CDCl3) 7.18 (2H, dd, J 7.2, 7.2 Hz), 7.76 (1H, m), 8.27 (1H, m), 8.57 (2H, m), 8.71 (1H, m), 8.83 (1H, m), 8.98 (1H, m), 9.10 (1H, m), 9.48 (1H, m), 10.10 (1H, s); m/z (ES+) 359.

Provenance & Evidence