2,4-Difluorophenylboronic acid → 3-(2,4-Difluorophenyl)-5-[4-fluoro-3-(pyridin-3-yl)phenyl]-[1,2,4]triazine

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Reaction Steps

5-[4-Fluoro-3-(pyridin-3-yl)phenyl]-3-methylsulfanyl-[1,2,4]triazine was coupled to 2,4-difluorophenylboronic acid by the method of Example 2 to give 3-(2,4-difluorophenyl)-5-[4-fluoro-3-(pyridin-3-yl)phenyl]-[1,2,4]triazine as a yellow solid: δH (400 MHz, CDCl3) 7.00-7.12 (2H, m), 7.42 (2H, m), 7.96 (1H, dd, J 2.0, 7.8 Hz), 8.27-8.36 (2H, m), 8.42 (1H, dd, J 2.5, 7.2 Hz), 8.70 (1H, s), 8.89 (1H, s), 9.66 (1H, s); m/z (ES+) 365.

Provenance & Evidence