反应详情

(4-Fluoro-3-trifluoromethylphenyl)oxoacetaldehyde was reacted with 4-methoxybenzenecarboximidic hydrazide hydriodide salt (2.37 g, 8.08 mmol) using the method described in Example 1 to give 5-(4-fluoro-3-trifluoromethylphenyl)-3-(4-methoxyphenyl)-[1,2,4]triazine as a yellow solid (1.13 g): δH (400 MHz, CDCl3) 3.92 (3H, s), 7.06-7.10 (2H, m), 7.44 (1H, t, J 9.2 Hz), 8.44-8.49 (1H, m), 8.56 (1H, dd, J 2.0, 6.7 Hz), 8.58-8.62 (2H, m), 9.54 (1H, s); m/z (ES+) 350.