Oxo[3-(2-oxopyrrolidin-1-yl)phenyl]acetaldehyde → 1-{3-[3-(2,4-Difluorophenyl)-[1,2,4]triazin-5-yl]phenyl}pyrrolidin-2-one

Participants

Reaction Steps

Oxo[3-(2-oxopyrrolidin-1-yl)phenyl]acetaldehyde was reacted with 2,4-difluorobenzenecarboximidic hydrazide hydriodide salt (0.74 g, 2.46 mmol) using the method described in Example 1 to give 1-{3-[3-(2,4-difluorophenyl)-[1,2,4]triazin-5-yl]phenyl}pyrrolidin-2-one as a yellow solid (0.5 g): δH H (400 MHz, d6-DMSO) 2.08-2.16 (2H, m), 2.55 (2H, t, J 8.2 Hz), 3.96 (2H, t, J 7.0 Hz), 7.34-7.39 (1H, m), 7.49-7.56 (1H, m), 7.65 (1H, t, J 8.0 Hz), 8.00-8.03 (1H, m), 8.16 (1H, d, J 7.8 Hz), 8.27-8.33 (1H, m), 8.59 (1H, t, J 1.8 Hz), 10.08 (1H, s); m/z (ES+) 353.

Provenance & Evidence