5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine → 3-(2,4-Difluorophenyl)-5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-[1,2,4]triazine

Participants

Reaction Steps

5 5-(3-Bromo-4-fluorophenyl)-3-(2,4-difluorophenyl)-[1,2,4]triazine (100 mg, 0.27 mmol) was coupled to 3-fluoro-2-tributylstannylpyridine (127 mg, 0.33 mmol) using the method described in Example 22 to give 3-(2,4-difluorophenyl)-5-[4-fluoro-3-(3-fluoropyridin-2-yl)phenyl]-[1,2,4]triazine as a pale yellow solid (60 mg): δH (400 MHz, CDCl3) 6.99-7.10 (2H, m), 7.39-7.47 (2H, m), 7.56-7.61 (1H, m), 8.29-8.36 (1H, m), 8.41-8.45 (1H, m), 8.53 (1H, dd, J 2.3, 6.7 Hz), 8.60-8.63 (1H, m), 9.68 (1H, s); m/z (ES+) 383.

Provenance & Evidence